Author(s): Long CL, Birkhahn RH, Geiger JW, Blakemore WS
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Abstract Whole body protein breakdown using 15N and skeletal muscle protein breakdown from urinary 3-methylhistidine were measured simultaneously in seven skeletal trauma and eight normal subjects on a standard hypocaloric, protein free diet. The trauma group had a 31\% greater resting metabolic energy expenditure than controls. The control males lost 3.73 mumol/kg/day of 3-methylhistidine which suggested a protein breakdown rate of 0.89 g P/kg/day. The control females lost 2.46 mumol/kg/day of 3-methylhistidine or a breakdown rate of 0.58 g P/kg/day. These parameters were 187\% greater for males and 163\% greater for females in the trauma group. The measured whole body protein breakdown rates were 3.64 g P/kg/day for the control males and 2.69 for females. Skeletal trauma increased both by 73\%. Skeletal trauma raised the muscle contribution to the whole body breakdown rate from 24.4 to 40.4\% for men and from 21.6 to 33.0\% for women. This disproportionate increase in muscle protein breakdown is consistent with muscle protein metabolism being most seriously affected by severe injury.
This article was published in Am J Clin Nutr
and referenced in Journal of Bioanalysis & Biomedicine