alexa Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin.


Journal of Addiction Research & Therapy

Author(s): Tomita K, van Bokhoven A, Jansen CF, Bussemakers MJ, Schalken JA

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Abstract Here we report on the role of alpha-catenin in the cellular localization of activated leukocyte cell adhesion molecule, ALCAM, and cadherin-mediated cell adhesion in human prostate cancer cells. Cell lines that have a functional E-cadherin-mediated cell adhesion (DU-145 and LNCaP) show ALCAM staining at cell-cell contacts. In contrast, in cell lines that lack alpha-catenin expression (ALVA-31, PC-3, and PPC-1), E-cadherin-mediated adhesion is disturbed and ALCAM staining is cytoplasmic. A role of alpha-catenin in the recruitment of E-cadherin and ALCAM to cell-cell contacts was established by transfection of an alpha-N-catenin construct into cell lines ALVA-31 and PC-3. This resulted not only in the correct assembly of E-cadherin/alpha-catenin complexes at the cell membrane but also in localization of ALCAM to cell-cell contacts, indicating that indeed alpha-catenin affects ALCAM localization. Copyright 2000 Academic Press. This article was published in Biochem Biophys Res Commun and referenced in Journal of Addiction Research & Therapy

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