alexa Copper-Catalyzed Oxy-Alkenylation of Homoallylic Alcohols to Generate Functional syn-1,3-Diol Derivatives.


International Journal of Advance Innovations, Thoughts & Ideas

Author(s): Holt D, Gaunt MJ

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Abstract A novel method for the synthesis of a wide range of functionalized 1,3-diol derivatives is reported. Employing a copper-catalyzed oxy-alkenylation strategy, a range of readily available, substituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts combine to form syn-1,3-carbonates in excellent yield and with high selectivity. Furthermore, the products formed are amenable to an iterative reaction sequence, thus affording highly complex polyketide-like fragments. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This article was published in Angew Chem Int Ed Engl and referenced in International Journal of Advance Innovations, Thoughts & Ideas

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