Author(s): Holt D, Gaunt MJ
Abstract Share this page
Abstract A novel method for the synthesis of a wide range of functionalized 1,3-diol derivatives is reported. Employing a copper-catalyzed oxy-alkenylation strategy, a range of readily available, substituted homoallylic alcohol derivatives and alkenyl(aryl) iodonium salts combine to form syn-1,3-carbonates in excellent yield and with high selectivity. Furthermore, the products formed are amenable to an iterative reaction sequence, thus affording highly complex polyketide-like fragments. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
This article was published in Angew Chem Int Ed Engl
and referenced in International Journal of Advance Innovations, Thoughts & Ideas