Author(s): Caldeira PC, Oliveira e Silva KR, Silva TA, de Mattos Camargo Grossma, Teixeira R,
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Abstract BACKGROUND: To investigate the correlation between anti-hepatitis C virus (HCV) antibodies in saliva and detection of HCV RNA in saliva and salivary glands of patients with chronic hepatitis C. METHODS: A total of 180 samples of saliva (131 non-stimulated and 49 stimulated) from 133 patients with chronic hepatitis C were tested by ELISA for presence of anti-HCV antibodies. Results were compared with the detection of HCV RNA in saliva and salivary glands samples. Pearson's chi-squared and Fisher's exact tests were performed for statistical analysis. RESULTS: Anti-HCV antibodies could be detected in 47/180 (26.1\%) saliva samples. In 11/47 (23.5\%) of these, HCV RNA was also detected. From the 133/180 (73.9\%) saliva samples with undetectable anti-HCV antibodies, 49/133 (36.8\%) were positive for HCV RNA at least in one saliva sample. From the 64 patients from whom salivary gland samples were available, 17/64 (26.6\%) had detectable anti-HCV antibodies in saliva, from which 2/17 (11.8\%) also had HCV RNA in the salivary gland. From the 47/64 (73.4\%) cases negative for anti-HCV antibodies in saliva, 10/47 (21.3\%) were positive for HCV RNA in salivary gland. CONCLUSIONS: Taken together, our results suggest that there is no correlation between the presence of anti-HCV antibodies in saliva and the detection of HCV RNA in saliva and salivary glands in patients with chronic hepatitis C. Nevertheless, as there was a statistically significant difference between detection of anti-HCV antibodies and HCV RNA in stimulated saliva, our study points toward the need for new research on mechanisms of HCV shedding in saliva. © 2012 John Wiley & Sons A/S. All rights reserved.
This article was published in J Oral Pathol Med
and referenced in Dentistry