Author(s): Naughton GK, Reggiardo D, Bystryn JC, Naughton GK, Reggiardo D, Bystryn JC
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Abstract We correlated the level of vitiligo antibodies to the extent of depigmentation in thirty-two patients with vitiligo. Vitiligo antibodies were assayed by protein A-sepharose immunoprecipitation method. Antibodies were present in four of eight (50\%) patients with minimal vitiligo (less than 2\% body surface involved), in nine of ten (90\%) patients with moderate vitiligo (2 to 5\% surface involved), and in thirteen of fourteen (93\%) patients with more extensive disease (greater than 5\% surface involved). The level of vitiligo antibodies in the three groups expressed as a binding index was 2.9\% +/- 2.03, 5.6\% +/- 2.92, and 8.0\% +/- 3.03 SD, respectively. These results suggest that there is a relation between the incidence and level of vitiligo antibodies and the extent of depigmentation in vitiligo.
This article was published in J Am Acad Dermatol
and referenced in Dermatology and Dermatologic Diseases