alexa Cortical inhibition is reduced in chronic and episodic migraine and demonstrates a spectrum of illness.


Journal of Pain Management & Medicine

Author(s): Aurora SK, Barrodale P, Chronicle EP, Mulleners WM

Abstract Share this page

Abstract BACKGROUND: The pathophysiological relationship between episodic migraine and chronic migraine is not fully understood. We aimed to examine transcranial magnetic stimulation (TMS) indices of cortical excitability in patients with episodic migraine (EM) and probable chronic migraine (PCM), and matched controls. METHODS: Cortical excitability was assessed at baseline with two well-established methods: phosphene thresholds (PT) and magnetic suppression of perceptual accuracy (MSPA) profiles. Five EM patients, five PCM patients, and five normal controls participated in the main study. In addition, two patients were reassessed after 30 days of treatment with topiramate. RESULTS: Both PT and MPSA measures were consistent in indicating a continuum of excitability across the three groups: PCM patients had the highest excitability, followed by EM, then controls. In the two treated patients MPSA profiles appeared to normalize at a 100 mg dosage. CONCLUSIONS: Patients with PCM appear to be characterized by very high cortical excitability. This may contribute to their greatly increased attack frequency. TMS-based methods will be important for future research examining the evolution of chronic migraine from episodic migraine over time. This article was published in Headache and referenced in Journal of Pain Management & Medicine

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 4th International Conference and Exhibition on Pain Medicine
    August 03-04, 2017 San Francisco USA
  • 5th International Conference and Exhibition on Pain Research and Management
    September 04-05, 2017 London UK

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version