alexa Corticotrophin-releasing factor receptors: from molecular biology to drug design.


Journal of Osteoporosis and Physical Activity

Author(s): Chalmers DT, Lovenberg TW, Grigoriadis DE, Behan DP, De Souza EB

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Abstract Corticotrophin-releasing factor (CRF) acts within both the brain and the periphery to coordinate the overall response of the body to stress. The involvement of the CRF systems in a variety of both CNS and peripheral disease states has stimulated great interest in this peptide as a potential site of therapeutic intervention. The recent cloning of multiple CRF receptor subtypes has precipitated a new era in CRF research that has allowed precise molecular, pharmacological and anatomical examination of mammalian CRF receptors. In this article, Derek Chalmers and colleagues highlight the major differences between the two classes of CRF receptors, CRF1 and CRF2, and a functionally related CRF-binding protein, and discuss the relevance of these sites to the ongoing development of CRF-based therapeutics.
This article was published in Trends Pharmacol Sci and referenced in Journal of Osteoporosis and Physical Activity

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