alexa Covariate imbalance and random allocation in clinical trials.
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Senn SJ

Abstract Share this page

Abstract A model is developed to estimate the effect of covariate imbalance on the size of a test of treatment efficacy in randomized clinical trials comparing two treatments when dispersion parameters are known. It is concluded that tests of homogeneity on the covariates should not be performed, that covariate imbalance is just as much a problem for large studies as for small ones in terms of effect on size, and that the effect of correlation between covariates and measures of efficacy is more complex than has previously been suggested. The best way to adjust for covariate imbalance is by an analysis of covariance.
This article was published in Stat Med and referenced in Journal of Addiction Research & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords