alexa Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Pharmacogenomics & Pharmacoproteomics

Author(s): Koyildiz ZC, Birman H, Olga V, AkgnDar K, Melikolu G,

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Abstract Crataegus (hawthorn) has long been used as a folk medicine all around the world. Most of the studies with Crataegus species focus on effects on heart failure and cardiovascular disease. The pharmacological effects of Crataegus have been attributed mainly to the content of flavonoids, procyanidin, aromatic acid and cardiotonic amines. The present study investigated the blood pressure and the structure of the coronary arterial wall of L-NAME-induced hypertensive rats given an aqueous leaf extract of C. tanacetifolia (100 mg/kg), for 4 weeks via gavage. It was observed that C. tanacetifolia, especially the hyperoside fraction, prevented L-NAME-induced hypertension in rats and had beneficial effects on the cardiovascular system. Copyright 2006 John Wiley & Sons, Ltd. This article was published in Phytother Res and referenced in Journal of Pharmacogenomics & Pharmacoproteomics

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