alexa CRISPR Cas system and its role in phage-bacteria interactions.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Data Mining in Genomics & Proteomics

Author(s): Deveau H, Garneau JE, Moineau S, Deveau H, Garneau JE, Moineau S, Deveau H, Garneau JE, Moineau S, Deveau H, Garneau JE, Moineau S

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Abstract Clustered regularly interspaced short palindromic repeats (CRISPRs) along with Cas proteins is a widespread system across bacteria and archaea that causes interference against foreign nucleic acids. The CRISPR/Cas system acts in at least two general stages: the adaptation stage, where the cell acquires new spacer sequences derived from foreign DNA, and the interference stage, which uses the recently acquired spacers to target and cleave invasive nucleic acid. The CRISPR/Cas system participates in a constant evolutionary battle between phages and bacteria through addition or deletion of spacers in host cells and mutations or deletion in phage genomes. This review describes the recent progress made in this fast-expanding field. This article was published in Annu Rev Microbiol and referenced in Journal of Data Mining in Genomics & Proteomics

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