alexa CRISPR--a widespread system that provides acquired resistance against phages in bacteria and archaea.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Journal of Data Mining in Genomics & Proteomics

Author(s): Sorek R, Kunin V, Hugenholtz P, Sorek R, Kunin V, Hugenholtz P, Sorek R, Kunin V, Hugenholtz P, Sorek R, Kunin V, Hugenholtz P

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Abstract Arrays of clustered, regularly interspaced short palindromic repeats (CRISPRs) are widespread in the genomes of many bacteria and almost all archaea. These arrays are composed of direct repeats that are separated by similarly sized non-repetitive spacers. CRISPR arrays, together with a group of associated proteins, confer resistance to phages, possibly by an RNA-interference-like mechanism. This Progress discusses the structure and function of this newly recognized antiviral mechanism. This article was published in Nat Rev Microbiol and referenced in Journal of Data Mining in Genomics & Proteomics

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