alexa Cross-presentation, dendritic cells, tolerance and immunity.


Journal of Clinical & Cellular Immunology

Author(s): Heath WR, Carbone FR

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Abstract This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC. This article was published in Annu Rev Immunol and referenced in Journal of Clinical & Cellular Immunology

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