alexa Cross-sectional analysis of adult diabetes type 1 and type 2 patients with diabetic microvascular complications from a German retrospective observational study.


Medicinal Chemistry

Author(s): Happich M, Breitscheidel L, Meisinger C, Ulbig M, Falkenstein P,

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Abstract OBJECTIVE: To obtain epidemiological data on the prevalence of predefined stages of diabetic microvascular complications from a representative cross-section of patients with existing microvascular complications of type 1 or type 2 diabetes in Germany. RESEARCH DESIGN AND METHODS: A cross-sectional, retrospective study of medical records of 705 type 1 and 1910 type 2 adult diabetic patients with a diagnosis of retinopathy and/or peripheral neuropathy and/or nephropathy before 2002 and treated in 2002 in Germany. RESULTS: Of 376 patients with type 1 diabetes having retinopathy, 59.3\% had mild or moderate non-proliferative retinopathy without macular oedema, 27.1\% had macular oedema, and 13.6\% had severe retinopathy without macular oedema. In 862 patients with type 2 diabetes, the distribution of retinopathy/maculopathy classes was 56.8\%, 35.5\%, and 7.7\%, respectively. Of 381 type 1 diabetes patients with observed peripheral neuropathy, 81.4\% had sensorimotor neuropathy, 8.9\% had diabetic foot conditions, and 9.7\% had lower extremity amputations because of diabetes. In 1005 patients with type 2 diabetes, the distribution of neuropathy classes was 78.2\%, 12.1\%, and 9.7\%, respectively. The proportions of patients with renal insufficiency in type 1 and type 2 diabetes groups were 15.3\% versus 13.5\%, respectively. CONCLUSIONS: The study suggests that there are considerable proportions of patients with progressive stages of microvascular complications related to type 1 and type 2 diabetes in Germany. This underlines the importance of improvement of optimal quality of care and frequent screening for preventing late diabetic microvascular complications and the necessity of effective intervention strategies to tackle this major public health problem. This article was published in Curr Med Res Opin and referenced in Medicinal Chemistry

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