alexa Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue.
Toxicology

Toxicology

Journal of Clinical Toxicology

Author(s): Scott DL, Otwinowski Z, Gelb MH, Sigler PB

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Abstract The 2.0 angstroms crystal structure of a complex containing bee-venom phospholipase A2 (PLA2) and a phosphonate transition-state analogue was solved by multiple isomorphous replacement. The electron-density map is sufficiently detailed to visualize the proximal sugars of the enzyme's N-linked carbohydrate and a single molecule of the transition-state analogue bound ot its active center. Although bee-venom PLA2 does not belong to the large homologous Class I/II family that encompasses most other well-studied PLA2s, there is segmental sequence similarity and conservation of many functional substructures. Comparison of the bee-venom enzyme with other phospholipase structures provides compelling evidence for a common catalytic mechanism.
This article was published in Science and referenced in Journal of Clinical Toxicology

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