alexa CSF characteristics in early-onset multiple sclerosis.


Journal of Pediatric Neurological Disorders

Author(s): Pohl D, Rostasy K, Reiber H, Hanefeld F

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The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was observed in 66%, blood-CSF barrier dysfunction in 13%, and oligoclonal IgG in 92% of the early-onset MS (EOMS) patients. CSF oligoclonal IgG supports the early diagnosis of MS in childhood with a sensitivity similar to adult-onset MS.

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This article was published in Neurology. and referenced in Journal of Pediatric Neurological Disorders

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