alexa C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Alvarez CP, Lasala F, Carrillo J, Muiz O, Corb AL,

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Abstract Ebola virus is a highly lethal pathogen responsible for several outbreaks of hemorrhagic fever. Here we show that the primate lentiviral binding C-type lectins DC-SIGN and L-SIGN act as cofactors for cellular entry by Ebola virus. Furthermore, DC-SIGN on the surface of dendritic cells is able to function as a trans receptor, binding Ebola virus-pseudotyped lentiviral particles and transmitting infection to susceptible cells. Our data underscore a role for DC-SIGN and L-SIGN in the infective process and pathogenicity of Ebola virus infection.
This article was published in J Virol and referenced in Journal of Bioterrorism & Biodefense

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