alexa CUL4B ubiquitin ligase in mouse development: a model for human X-linked mental retardation syndrome?
Molecular Biology

Molecular Biology

Journal of Cytology & Histology

Author(s): Zhao Y, Sun Y

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Abstract CUL4B, a member of the cullin-RING ubiquitin ligase family, is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues, while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.
This article was published in Cell Res and referenced in Journal of Cytology & Histology

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