alexa Curcumin attenuates diet-induced hypercholesterolemia in rats.
Gastroenterology

Gastroenterology

Journal of Liver

Author(s): Hossam M M Arafa

Abstract Share this page

Background: Curcumin (a component of turmeric) has long been used as aspice and food-coloring agent. In experimental animals, curcumin has shown anti-diabetic, anti-inflammatory,cytotoxic and anti-oxidant properties. Material/Methods: The possible hypolipidemic effect of curcuminwas investigated in rats fed a high-cholesterol diet (HCD). The lipid profile and activities of aspartateaminotransferase (AST) and alanine aminotransferase (ALT) were assessed in serum, as well as anti-oxidantparameters in liver tissues. Results: Feeding the animals a high cholesterol diet (HCD) for 7 consecutivedays (1 ml 100 g(-1)) resulted in marked hypercholesterolemia, increased serum level of low-density lipoproteincholesterol (LDL-C), but a decreased serum high-density lipoprotein cholesterol (HDL-C). Curcumin admixedwith the diet (0.5% w/w) decreased serum total cholesterol (TC) by about 21% and LDL-C by 42.5%, butit increased serum HDL by 50%. The atherogenic indices (LDL-C/HDL-C and TC/HDL-C) were reduced by 52%and 35%, respectively. Curcumin also decreased the enzyme activities of serum AST and ALT, which wereincreased in HCD animals. Conclusions: Curcumin showed an obvious hypocholesterolemic effect that couldbe due to an effect on cholesterol absorption, degradation or elimination, but not due to an anti-oxidantmechanism. This could be supported by the finding in our study that neither HCD nor curcumin-admixedHCD had any effects on the liver content of glutathione (GSH) or superoxide dismutase (SOD) activity.Thus one could argue that ingestion of curcumin-containing spices in the diet, especially one rich infats, could have a lipid-lowering effect.

  • To read the full article Visit
  • Subscription
This article was published in Med Sci Monit and referenced in Journal of Liver

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords