alexa Cure of Burkitt's lymphoma. Ten-year follow-up of 157 Ugandan patients


Chemotherapy: Open Access

Author(s): Ziegler JL, Magrath IT, Olweny CL

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192 Ugandan patients with Burkitt's lymphoma were treated with various regimens containing high-dose cyclophosphamide. 21 patients died during induction therapy, and 14 died after partial responses. Of 157 patients who responded completely to treatment, 16 were lost to follow-up (10 in 69 died and 72 (51%) are alive and disease-free. 31 of the long-term survivors have relapsed at least once and have been successfully retreated. Overall, 34 surviving patients had central-nervous-system involvement, also successfully treated. It is concluded that Burkitt's lymphoma is curable in at least 50% of patients, and that relapse and central-nervous-system involvement are not incompatible with long survival.

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This article was published in Lancet and referenced in Chemotherapy: Open Access

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