alexa Cyclin E in human cancers.
Oncology

Oncology

Journal of Carcinogenesis & Mutagenesis

Author(s): Donnellan R, Chetty R

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Abstract Regulators of the cell cycle such as cyclin E play an important part in neoplasia. The cyclin E protein forms a partnership with a specific protein kinase. This complex phosphorylates key substrates to initiate DNA synthesis. Cyclin-dependent kinase inhibitors (CKIs) are able to suppress the activity of cyclin E. Various substances (including proteins produced by oncogenic viruses) affect cyclin E directly or indirectly through an interaction with CKIs. These interactions are important in elucidating the mechanisms of neoplasia. They may also provide prognostic information in a wide range of common cancers. Cyclin E may even be a target for treatment of cancers in the future.
This article was published in FASEB J and referenced in Journal of Carcinogenesis & Mutagenesis

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