alexa Cycloartane glycosides from Sutherlandia frutescens.
Pharmaceutical Sciences

Pharmaceutical Sciences

Medicinal & Aromatic Plants

Author(s): Fu X, Li XC, Smillie TJ, Carvalho P, Mabusela W,

Abstract Share this page

Abstract Four new cycloartane glycosides, sutherlandiosides A-D (1-4), were isolated from the South African folk medicine Sutherlandia frutescens and their structures established by spectroscopic methods and X-ray crystallography as 1 S,3 R,24S,25-tetrahydroxy-7S,10S-epoxy-9,10- seco-9,19-cyclolanost-9(11)-ene 25-O-beta-D-glucopyranoside (1), 3R,7S,24S,25-tetrahydroxycycloartan-1-one 25-O-beta-D-glucopyranoside (2), 3R,24S,25-trihydroxycycloartane-1,11-dione 25-O-beta-D-glucopyranoside (3), and 7S,24S,25-trihydroxycycloart-2-en-1-one 25-O-beta-D-glucoyranoside (4). Compound 1 represents the first secocycloartane skeleton possessing a 7,10-oxygen bridge. Compounds 2- 4 are also the first examples of naturally occurring cycloartanes with a C-1 ketone functionality. Biosynthetic considerations and chemical evidence suggest that the presence of the C-1 ketone in 2 may facilitate the ring opening of the strained cyclopropane system.
This article was published in J Nat Prod and referenced in Medicinal & Aromatic Plants

Relevant Expert PPTs

Relevant Speaker PPTs

  • Linhua Zhao
    The effi cacy of a Chinese herbal formula GQD on type 2 diabetes and its mechanism
    PPT Version | PDF Version
  • Bonamali Pal
    Metal-TiO2 nano-photocatalysts for detoxification of toxic pesticides, dyes, polyaromatics pollutants and bacteria under UV-sunlight irradiation
    PPT Version | PDF Version
  • Yi-Cheng Hu
    Detection of a negative correlation between prescription of Chinese herbal products containing coumestrol, genistein or daidzein and risk of subsequent endometrial cancer among tamoxifentreated female breast cancer survivors in Taiwan between 1998 and 2008: A population-based study
    PPT Version | PDF Version
  • Hawa ZE Jaafar
    Involvement of elicitated Labisia pumila Benth. biofluids in the alleviation of chemotoxicity effect and antitumor activity
    PPT Version | PDF Version
  • Mariam Aslam
    Herbal medicines: Product licence to traditional herbal registration in the UK
    PPT Version | PDF Version
  • Dave Ray
    Nutrition & HAIR & SCALP DIALOGUE
    PPT Version | PDF Version
  • Helene Corriveau
    Evaluation of risk of fall on frail elderly: The reliability and validity study of an obstacle course, the Sherbrooke Functional Evaluation of the Risk of falls in Elderly (SFERE)
    PPT Version | PDF Version
  • Michel Tousignant
    Telerehabilitation for Total knee arthroplasty: Is there an issue related to virtual treatment without hands-on mobilisation for knee range of motion recovery?
    PPT Version | PDF Version

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version