alexa Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat.


Journal of Clinical Toxicology

Author(s): Frederickson CJ, Klitenick MA, Manton WI, Kirkpatrick JB

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Abstract Zinc was measured in whole hippocampus and in hippocampal sub-regions by stable-isotope dilution mass spectrometry. In both man and the rat, the most zinc (102-145 ppm, dry weight) was found in the hilar region, the least (27-35) in the fimbria. The amount of zinc directly associated with mossy-fiber axons was estimated to be approximately 8\% of the total zinc in the hippocampus, and the concentration of mossy-fiber zinc was estimated at 220-300 microM. Methodological and theoretical implications of the quantitative findings were discussed.
This article was published in Brain Res and referenced in Journal of Clinical Toxicology

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