Author(s): Wong KF, Zhang YM, Chan JK
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Abstract The group of putative natural killer cell lymphomas, also known as NK/T cell lymphomas (nasal and nasal-type) has been characterized only in recent years. Whilst a good amount of clinical information has been gathered on this group of uncommon lymphoid neoplasms, there is little information on the cytogenetic or molecular alterations. A review of the literature shows that chromosomal abnormalities are indeed commonly found in these tumours, and aberrations involving chromosome 6q are most frequent. Other non-random abnormalities include +X, i(1q), i(7q), +8, del(13q), del(17p), i(17q), and 11q23 rearrangement. It appears that deletions of the chromosome 6 at around q21-23 region is the commonest recurrent chromosomal abnormality, and fluorescence in situ hybridisation studies have confirmed the occurrence of deletions at 6q22-23 in the CD3- CD56+ tumour cells. Search for the involved genes located in this chromosome region can potentially shed light on the molecular pathogenesis of the natural killer cell neoplasms.
This article was published in Leuk Lymphoma
and referenced in Journal of Blood Disorders & Transfusion