alexa Cytotoxic antibodies in congenital hypothyroidism.
Diabetes & Endocrinology

Diabetes & Endocrinology

Journal of Thyroid Disorders & Therapy

Author(s): Bogner U, Grters A, Sigle B, Helge H, Schleusener H, Bogner U, Grters A, Sigle B, Helge H, Schleusener H

Abstract Share this page

Abstract Antibody-dependent cell-mediated cytotoxicity was determined in serum samples from 61 patients with congenital hypothyroidism (CH) and 46 of their mothers, using a 51chromium release assay with human thyroid cells. Such cytotoxic antibodies were found in 31\% of the children and 24\% of their mothers. In the 12 (of 37) newborn infants with hypothyroidism (group 1) who had positive tests, the median cell lysis was 20.1\% compared to 4\% in healthy newborns. In the 7 (of 29) mothers who had positive tests, the median lysis was 21.3\%. In 24 older children with CH (group 2), cytotoxic activity was found in 6, and in them the median lysis was 19.7\%; 4 of their mothers had increased lytic activity (median, 20.6\%). In 96\% of the mother-infant pairs concordance existed between the cytotoxic activity in mothers and their children. Increased thyroid cell lysis was found in 6 of 20 children with athyrosis (30\%) and in 6 of 23 children with an ectopic gland (50\%), but in only 1 of 14 children with a normal gland. Thyroglobulin antibodies were detected in 2 and antithyroid microsomal antibodies in 3 children-mother pairs. TSH receptor antibodies were present in 5 children and 3 of their mothers. The results indicate that intrauterine autoimmune thyroiditis could be involved in the pathogenesis of CH in some patients. This article was published in J Clin Endocrinol Metab and referenced in Journal of Thyroid Disorders & Therapy

Relevant Expert PPTs

Relevant Speaker PPTs

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version