Author(s): Bogner U, Grters A, Sigle B, Helge H, Schleusener H, Bogner U, Grters A, Sigle B, Helge H, Schleusener H
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Abstract Antibody-dependent cell-mediated cytotoxicity was determined in serum samples from 61 patients with congenital hypothyroidism (CH) and 46 of their mothers, using a 51chromium release assay with human thyroid cells. Such cytotoxic antibodies were found in 31\% of the children and 24\% of their mothers. In the 12 (of 37) newborn infants with hypothyroidism (group 1) who had positive tests, the median cell lysis was 20.1\% compared to 4\% in healthy newborns. In the 7 (of 29) mothers who had positive tests, the median lysis was 21.3\%. In 24 older children with CH (group 2), cytotoxic activity was found in 6, and in them the median lysis was 19.7\%; 4 of their mothers had increased lytic activity (median, 20.6\%). In 96\% of the mother-infant pairs concordance existed between the cytotoxic activity in mothers and their children. Increased thyroid cell lysis was found in 6 of 20 children with athyrosis (30\%) and in 6 of 23 children with an ectopic gland (50\%), but in only 1 of 14 children with a normal gland. Thyroglobulin antibodies were detected in 2 and antithyroid microsomal antibodies in 3 children-mother pairs. TSH receptor antibodies were present in 5 children and 3 of their mothers. The results indicate that intrauterine autoimmune thyroiditis could be involved in the pathogenesis of CH in some patients.
This article was published in J Clin Endocrinol Metab
and referenced in Journal of Thyroid Disorders & Therapy