Author(s): Chang YC, Chou MY
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Abstract OBJECTIVES: Numerous studies have revealed that conventional glass-ionomer cements might release fluoride into an aqueous environment. The objective of this study was to examine the effects of fluoride on human pulp cells in vitro. STUDY DESIGN: H33258 fluorescence, cell proliferation, protein synthesis, and mitochondrial activity assay were used to investigate the pathobiological effects of fluoride on cultured human pulp cells. RESULTS: Fluoride was found to be a cytotoxic agent to cultured human pulp cells by inhibiting cell growth, proliferation, mitochondrial activity, and protein synthesis. CONCLUSIONS: Fluoride release has significant potential for pulpal toxicity.
This article was published in Oral Surg Oral Med Oral Pathol Oral Radiol Endod
and referenced in Dentistry