alexa Damage to histaminergic tuberomammillary neurons and other hypothalamic neurons with traumatic brain injury.


Journal of Clinical & Experimental Neuroimmunology

Author(s): Valko PO, Gavrilov YV, Yamamoto M, Finn K, Reddy H

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The need for increased sleep after traumatic brain injury is a common and disabling complaint, yet its etiology is unknown. Previous studies have demonstrated diffuse damage to various hypothalamic systems, but the integrity of the histaminergic tuberomammillary nucleus, a major arousal-promoting system located in the posterior hypothalamus, has never been examined in head trauma patients. Here, we demonstrate that severe head trauma is associated with a marked loss (41%) of histaminergic neurons. Reduced histamine signaling may contribute to increased sleep need, and therapies that enhance histaminergic tone may improve arousal after head trauma or other conditions.

This article was published in Ann Neurol and referenced in Journal of Clinical & Experimental Neuroimmunology

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