alexa Damage to the liver, kidney, and testis with reference to burden of heavy metals in yellow-necked mice from areas around steelworks and zinc smelters in Poland.
Nutrition

Nutrition

Vitamins & Minerals

Author(s): DamekPoprawa M, SawickaKapusta K

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Abstract The influence of the steelworks in Warsaw and Krakow as well as the zinc smelters in Bukowno and Miasteczko Slaskie on lead, cadmium, zinc and iron concentrations and the structure of selected tissues of yellow-necked mice were analysed. The Borecka Forest was chosen as a control area. The highest concentrations of lead, 172.36 g/g dry weight, and cadmium, 23.58 g/g, were detected in the femurs and kidneys, respectively, of rodents caught in Bukowno. Zinc and iron concentrations ranged over physiological values. No histopathological changes were observed in analysed tissues of all rodents in the control area. Damage occurred in the liver and kidneys of animals from all other sites and in the testes of rodents from Bukowno. Decreased glycogen content, interstitial fibrosis, and increased number of pyknotic nuclei as well as necrosis were seen in hepatocytes. In the kidneys hyperplasia of the tubules, atrophy of glomeruli, interstitial fibrosis and necrosis were observed. Degenerate cells were present in the lumen of seminiferous tubules of animals from the Bukowno area. Even relatively low concentrations of lead and cadmium, like those found in the liver and kidneys of rodents from the neighbourhood of the steelworks, caused histopathological changes.
This article was published in Toxicology and referenced in Vitamins & Minerals

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