alexa Darunavir is a good third-line antiretroviral agent for HIV type 1-infected patients failing second-line protease inhibitor-based regimens in South India.
Microbiology

Microbiology

Journal of Antivirals & Antiretrovirals

Author(s): Saravanan S, Madhavan V, Balakrishnan P, Smith DM, Solomon SS,

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Abstract Eleven protease mutations have been associated with reduced susceptibility to darunavir. In this study of 87 HIV-1-infected patients experiencing virological failure to second-line regimens containing protease inhibitors boosted with ritonavir (viral load >1,000 HIV RNA copies/ml), we observed a low prevalence (3\%) of ≥3 darunavir resistance-associated mutations, indicating that this drug may be a good option for third-line antiretroviral therapy in southern India.
This article was published in AIDS Res Hum Retroviruses and referenced in Journal of Antivirals & Antiretrovirals

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