alexa DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells.
Immunology

Immunology

Immunotherapy: Open Access

Author(s): Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC,

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Abstract Dendritic cells (DC) capture microorganisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present these in antigenic form to resting T cells and thus initiate adaptive immune responses. Here, we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. We propose that DC-SIGN efficiently captures HIV-1 in the periphery and facilitates its transport to secondary lymphoid organs rich in T cells, to enhance infection in trans of these target cells.
This article was published in Cell and referenced in Immunotherapy: Open Access

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