alexa D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study.

Journal of Thrombosis and Circulation: Open Access

Author(s): Rectenwald JE, Myers DD Jr, Hawley AE, Longo C, Henke PK, , Rectenwald JE, Myers DD Jr, Hawley AE, Longo C, Henke PK,

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Abstract Current plasma markers for diagnosis of deep venous thrombosis (DVT) allow for exclusion of the diagnosis, but lack adequate specificity to establish the diagnosis. Thus, a prospective study was performed to determine the sensitivity and specificity of plasma assays for D-dimer, soluble P-selectin (P-selectin), and total microparticles in patients with documented DVT by duplex ultrasound. Three groups of individuals were examined: 30 normals; 22 positive for DVT on duplex ultrasound (Group 2); and 21 symptomatic, but negative on duplex ultrasound for DVT (Group 3). Group 1 individuals had D-dimer values of 1.53 +/- 0.12 mg/l and P-selectin values of 0.34 +/- 0.05 ng/mg total protein. Group 2 vs. Group 3 individuals had D-dimer values of 7.57 +/- 2.03 vs. 3.19 +/- 0.79 mg/l, p = 0.02; P-selectin values of 0.98 +/- 0.11 vs. 0.55 +/- 0.08 ng/mg total protein, p < 0.01; and micro-particle values of 129 +/- 17\% vs. 99 +/- 12\% of control, p = ns. Using a logistic regression model with dichotomous variables, we determined a sensitivity of 73\%, specificity of 81\%, and accuracy of 77\% when combining D-dimer, soluble P-selectin, and total microparticles to differentiate Group 2 from Group 3 patients. Logistic regression using continuous variables yielded similar results (p = 0.05). This study demonstrates that plasma markers for DVT can be developed and achieve moderate sensitivity and specificity in diagnosing DVT. However for clinical applicability, the sensitivity/specificity will need to be improved. These studies also suggest the importance of soluble P-selectin in assessing DVT in humans. This article was published in Thromb Haemost and referenced in Journal of Thrombosis and Circulation: Open Access

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