Author(s): Lathia JD, Heddleston JM, Venere M, Rich JN
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Abstract Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy. Copyright © 2011 Elsevier Inc. All rights reserved.
This article was published in Cell Stem Cell
and referenced in Journal of Stem Cell Research & Therapy