alexa Decoding cytosolic Ca2+ oscillations.


Journal of Transplantation Technologies & Research

Author(s): Parekh AB

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Abstract A rise in cytosolic Ca(2+) concentration is used as a universal signalling mechanism to control biological processes as diverse as exocytosis, contraction, cell growth and cell death. Ca(2+) signals are often presented to cells in the form of Ca(2+) oscillations, with signalling information encoded in both amplitude and frequency of the Ca(2+) spikes. Recent studies have revealed that the sub-cellular spatial profile of the Ca(2+) oscillation is also important in activating cellular responses, thereby suggesting a new mechanism for extracting information from the ubiquitous Ca(2+) oscillation. Copyright © 2010 Elsevier Ltd. All rights reserved. This article was published in Trends Biochem Sci and referenced in Journal of Transplantation Technologies & Research

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