alexa Decreased striatal dopaminergic innervation in REM sleep behavior disorder.


Journal of Sleep Disorders & Therapy

Author(s): Albin RL, Koeppe RA, Chervin RD, Consens FB, Wernette K,

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Abstract REM sleep behavior disorder (RBD) is a possible herald of neurodegenerative disorders with parkinsonism. The authors determined the density of striatal dopaminergic terminals with [11C]dihydrotetrabenazine PET in six elderly subjects with chronic idiopathic RBD and 19 age-appropriate controls. In subjects with RBD, there were significant reductions in striatal [11C]dihydrotetrabenazine binding, particularly in the posterior putamen.
This article was published in Neurology and referenced in Journal of Sleep Disorders & Therapy

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