alexa Defective adherence of polymorphonuclear leukocytes to nylon induced by thalassemic serum.
Haematology

Haematology

Journal of Blood Disorders & Transfusion

Author(s): Bassaris HP, Lianou PE, Skoutelis AT, Papavassiliou JT, Phair JP, Bassaris HP, Lianou PE, Skoutelis AT, Papavassiliou JT, Phair JP

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Abstract The effects of sera obtained from 18 patients with homozygous beta-thalassemia on the adherence and chemotaxis of normal polymorphonuclear leukocytes (PMNLs) was studied. The adherence of PMNLs suspended in thalassemic serum was 3.1\% +/- 2.5\% (mean +/- SD) compared with 17.9\% +/- 8.0\% adherence in control serum (P less than 0.00001). Zymosan-treated thalassemic serum did not generate chemotactic factors, and zymosan-treated normal serum did not induce chemotaxis of PMNLs suspended in thalassemic serum. When added to zymosan-treated normal plasma, thalassemic serum inhibited augmentation of PMNL adherence to nylon columns. These abnormalities were due to a heat-labile factor(s) in the sera of patients with thalassemia. Suspending PMNLs in heated thalassemic serum (56 C for 30 min) resulted in an increase of adherence to 14.6\% +/- 6.2\% (P less than 0.0001). PMNLs suspended in heated thalassemic serum responded normally to chemotactic attractants.
This article was published in J Infect Dis and referenced in Journal of Blood Disorders & Transfusion

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