alexa Defective barrier function in melasma skin.


Journal of Pigmentary Disorders

Author(s): Lee DJ, Lee J, Ha J, Park KC, Ortonne JP,

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Abstract BACKGROUND: Melasma is characterized by increased pigmentation and photodamaged features, which include solar elastosis. Recently, we detected the downregulation of the genes most associated with lipid metabolism using microarray analysis in melasma. These findings suggested that lesional skin may have different biophysical characteristics, and, in particular, an altered skin barrier function. OBJECTIVE: To determine the cutaneous biophysical characteristics of melasma. METHODS: The melanin index, erythema index, stratum corneum hydration, sebum content and transepidermal water loss (TEWL) were measured for lesional and perilesional normal skin of 16 melasma patients and then compared. In addition, a skin biopsy was performed on 11 of the 16 study subjects to measure stratum corneum thickness and to study the protein expressions of PPAR-α and ALOX15B. RESULTS: Melanin index, erythema index and stratum corneum hydration were significantly higher in lesional skin than in perilesional normal skin. No significant difference was found between lesional and normal skin in terms of basal TEWL level or sebum content. However, the rate of TEWL after barrier perturbation was significantly higher for lesional skin, and the barrier recovery rate was significantly delayed. Furthermore, a trend towards thinned stratum corneum was observed for lesional skin, and this was correlated with barrier recovery rate. The expressions of PPAR-α and ALOX15B were variable in the samples. CONCLUSIONS: Melasma skin is characterized by impaired stratum corneum integrity and a delayed barrier recovery rate. © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology. This article was published in J Eur Acad Dermatol Venereol and referenced in Journal of Pigmentary Disorders

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