Author(s): Schneider JS, Roeltgen DP
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Abstract Cognitive deficits following chronic exposure to low doses of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were studied in monkeys asymptomatic for a gross parkinsonian motor disorder. Monkeys developed deficits in performance of delayed matching-to-sample, visual pattern discrimination reversal, and object retrieval tasks, all tasks that rely upon the integrity of the frontal-striatal axis. Performance on a visual pattern discrimination task, that relies primarily on inferotemporal cortex function, remained intact. These results extend previous findings of frontal-like cognitive deficits in MPTP-treated monkeys and further support the use of this model for studying the pathophysiology of the cognitive deficits associated with parkinsonism.
This article was published in Brain Res
and referenced in Journal of Gerontology & Geriatric Research