alexa Deltamethrin induces altered expression of P53, Bax and Bcl-2 in rat brain.
Toxicology

Toxicology

Journal of Environmental & Analytical Toxicology

Author(s): Wu A, Ren T, Hu Q, Liu Y, Wu A, Ren T, Hu Q, Liu Y

Abstract Share this page

Abstract In this study we investigated the effects of deltamethrin on the expression of P53, Bax and Bcl-2 in rat brain. Immunohistochemical analysis demonstrated that the immunoreactivity for P53 was markedly increased in the cerebral cortex and hippocampus at 5 h after deltamethrin treatment, and maintained at an increased level at 24 and 48 h, whereas little immunoreactivity for P53 was seen in the same brain regions of control rats. The immunostaining for Bax was also elevated in the same brain regions, showing the same time course of P53 expression after deltamethrin treatment. However, the immunolabeling for Bcl-2 was markedly decreased at 24 h after a transient increase at 5 h following deltamethrin treatment. These results indicate that deltamethrin leads to the persistent increase of P53 and Bax expression and transient elevation of Bcl-2 expression, resulting in an increased ratio of Bax to Bcl-2, which may contribute to apoptotic cell death in rat brain following deltamethrin treatment.
This article was published in Neurosci Lett and referenced in Journal of Environmental & Analytical Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords