alexa DeltaznuADeltapurE Brucella abortus 2308 mutant as a live vaccine candidate.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Yang X, Thornburg T, Walters N, Pascual DW

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Abstract To create a new, safe brucellosis live vaccine, a double mutant strain was constructed from Brucella abortus 2308. Using the DeltaznuA B. abortus 2308 mutant, a second mutation was introduced by deleting purE gene. The DeltaznuA DeltapurE B. abortus 2308 strain was less capable of surviving in macrophages. When evaluated in vivo, it was cleared within 8 weeks (wks) from mice, causing significantly less inflammation than spleens obtained from wild-type B. abortus 2308-infected mice. Furthermore, two doses of DeltaznuA DeltapurE B. abortus 2308 conferred 0.79 log protection, similar to S19 as did a single dose of DeltaznuA B. abortus 2308. Thus, this study shows the DeltaznuA DeltapurE B. abortus 2308 strain to be a potential livestock vaccine candidate. This article was published in Vaccine and referenced in Journal of Bioterrorism & Biodefense

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