alexa Dendritic cell-dead cell interactions: implications and relevance for immunotherapy.
Pharmaceutical Sciences

Pharmaceutical Sciences

Journal of Clinical & Experimental Pharmacology

Author(s): Fonteneau JF, Larsson M, Bhardwaj N

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Abstract Dendritic cells are a system of antigen-presenting cells with an essential role in the initiation and development of immune responses against infections or tumors. Their unique capacity to stimulate T cells is being adapted for use in immunotherapy. In this review, we focus on their ability to interact with dead cells and, notably, to present exogenous antigens acquired from them to CD8+ T cells. We also discuss the role of this unique antigen presentation pathway for immunotherapeutic development.
This article was published in J Immunother and referenced in Journal of Clinical & Experimental Pharmacology

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