alexa Density of tumor-infiltrating lymphocytes correlates with disease recurrence and survival in patients with large non-small-cell lung cancer tumors.


Journal of Clinical & Cellular Immunology

Author(s): Kilic A, Landreneau RJ, Luketich JD, Pennathur A, Schuchert MJ

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Abstract BACKGROUND: The density of tumor-infiltrating lymphocytes (TIL) in lung cancer is variable and may have an impact on disease course. We reviewed the histology of lobectomy specimens from patients with pathologic stage IA-IB non-small-cell lung cancer to determine the impact of TILs on recurrence and survival. MATERIALS AND METHODS: Two hundred nineteen lobectomies performed between 2002 and 2005 for stage IA-IB non-small-cell lung cancer were reviewed. Patients were stratified according to tumor size. Infiltrating patterns were graded as follows: group 1 (none to mild infiltrate) or group 2 (moderate to severe infiltrate). Recurrence rates and disease-free survival were compared between groups in each tumor size cohort. RESULTS: A higher density of TILs was associated with lower disease recurrence (60\%, group 1 versus 21\%, group 2, P=0.02) and improved 5-y disease-free survival (35.9\%, group 1 versus 75.6\%, group 2, P=0.04) in patients with tumors 5 cm or greater in diameter. There were no correlations in patients with smaller tumors. CONCLUSIONS: A higher degree of TILs within large node-negative non-small-cell lung cancer correlates with decreased risk of disease recurrence and improved disease-free survival. This subset of patients with tumor infiltration needs to be examined more closely with regards to outcomes of adjuvant chemotherapy. Copyright © 2011 Elsevier Inc. All rights reserved. This article was published in J Surg Res and referenced in Journal of Clinical & Cellular Immunology

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