alexa Department of Pharmaceutical Chemistry,
Chemical Engineering

Chemical Engineering

Journal of Chromatography & Separation Techniques

Author(s): R Gopinath, S Rajan, S N Meyyanathan, N Krishnaveni, B Suresh

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A simple, selective, rapid, precise and economical reverse phase HPLC method has been developed for the simultaneous estimation of paracetamol and aceclofenac from pharmaceutical dosage forms. The method was carried out on a Hichrom C18 (25 cm×4.6 mm i.d., 5 µ) column with a mobile phase consisting of acetonitrile:20 mM phosphate buffer (pH 5.0) (60:40 v/v) at a flow rate of 0.8 ml/min. Detection was carried out at 265 nm. Etoricoxib was used as an internal standard. The retention time of paracetamol, aceclofenac and etoricoxib was 4.75, 6.44 and 8.83 min, respectively. The developed method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and solution stability. The proposed method can be used for the estimation of these drugs in combined dosage forms.

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This article was published in Indian journal of pharmaceutical sciences and referenced in Journal of Chromatography & Separation Techniques

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