alexa Depression and suicide ideation n chronic hepatitis C patients untreated and treated with interferon: prevalence prevention and treatment.
Medicine

Medicine

General Medicine: Open Access

Author(s): Lucaciu LA, Dumitrascu DL

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Interferon-based therapies were until recently the standard of care in chronic hepatitis C (CHC), despite their side effects. We aimed to review the available data on the depression and suicide in CHC patients receiving or not antiviral therapy based on interferon treatment. A PubMed search was performed, identifying relevant papers published between 1991 and January 2015 concerning major depressive disorders and suicidal risk in patients under interferon. A total of 21 relevant papers were retrieved. Prospective studies reported depression as the most common side effect of interferon, with an incidence peak between weeks 8 and 12 of therapy. Suicide risk was analyzed in 7 of the reviewed articles, and case reports of attempted suicide were discussed. Moreover, studies have shown that pretreatment with serotonin reuptake inhibitors is a good strategy for the prevention of interferon-induced depression.

This article was published in Annals of Gastroenterology and referenced in General Medicine: Open Access

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