alexa Depressive symptoms in HIV-infected patients treated with highly active antiretroviral therapy.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Silveira MP, Guttier MC, Pinheiro CA, Pereira TV, Cruzeiro AL,

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Abstract INTRODUCTION: The prevalence of depressive disorders in HIV-infected patients ranges from 12\% to 66\% and is undiagnosed in 50\% to 60\% of these patients. Depression in HIV-infected individuals may be associated with poor antiretroviral treatment (ART) outcomes, since it may direct influence compliance. OBJECTIVE: To assess the presence of symptoms and risk factors for depression in patients on ART. METHODS: Cross-sectional study. Certified interviewers administered questionnaires and the Beck Depression Inventory (BDI), and participants' self-reported compliance to ART. Clinical and laboratory variables were obtained from clinical records. Patients with BDI > 12 were defined as depressed. RESULTS Out of the 250 patients invited to participate, 246 (98\%) consented. Mean age was 41 ± 9.9 years; most were male (63\%). Income ranged from 0-14 Brazilian minimum wages. AIDS (CDC stage C) had been diagnosed in 97\%, and 81\% were in stable immune status. One hundred ninety-one (78\%) reported compliance, and 161 (68\%) had undetectable viral loads. The prevalence of depressive symptoms was 32\% (95\% CI 26-40). In multivariate analysis, depressive symptoms were significantly associated with income (prevalence ratio [PR] = 0.85; 95\% CI 0.74-0.97; p = 0.02). CONCLUSIONS: Depressive symptoms are frequent in patients on ART, and are associated with low income.
This article was published in Rev Bras Psiquiatr and referenced in Journal of Clinical & Cellular Immunology

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