alexa Derivatization of benz[a]anthracene metabolites for detection by laser excited Shpol'skii spectrometry.
Geology & Earth Science

Geology & Earth Science

Oil & Gas Research

Author(s): Weeks S, Gilles S, Dobson R, Senne S, DSilva AP, Weeks S, Gilles S, Dobson R, Senne S, DSilva AP, Weeks S, Gilles S, Dobson R, Senne S, DSilva AP, Weeks S, Gilles S, Dobson R, Senne S, DSilva AP

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Abstract The polar metabolites of polycyclic aromatic compounds (PACs) are of significant oncological interest. In contrast to parent PACs, isomer selective detection of polar PACs by laser excited Shpol'skii spectrometry (LESS) is severely limited by excessively broadened spectra and rapid photodegradation in n-alkane solvents. To minimize these limitations a 10-min derivatization procedure was developed to produce corresponding methoxy compounds, that exhibit the Shpol'skii effect. By use of the extraction and permethylation procedure, the selective detection of a mixture of hydroxy-benz[a]anthracene isomers spiked at the low picogram level into urine and blood matrices was achieved. A detection limit for 1-hydroxybenz[a]anthracene was 0.6 part per trillion, or 12 fg (0.05 fmol) on a 20-microL sample.
This article was published in Anal Chem and referenced in Oil & Gas Research

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