alexa Design and synthesis of substrates for model ribosomal reactions.
Chemical Engineering

Chemical Engineering

Journal of Chemical Engineering & Process Technology

Author(s): Bayryamov SG, Vassilev NG, Rangelov MA, Mladjova AP, Petkov DD

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Abstract 2'/3'-O-[Bz(NO(2))-Orn(Boc)]-5'-O-Piv-Ado (1) and its deoxy analog: 3'-O-[Bz(NO(2))-Orn(Boc)]-5'-O-Piv-2'-dAdo (2) were designed and synthesized as substrates for the model ribosome reaction we used to demonstrate the crucial role of A76 2'-OH of peptidyl-tRNA in the rate acceleration of peptide bond formation during protein biosynthesis.
This article was published in Protein Pept Lett and referenced in Journal of Chemical Engineering & Process Technology

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