alexa Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole.


Natural Products Chemistry & Research

Author(s): Yang XD, Wan WC, Deng XY, Li Y, Yang LJ,

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Abstract A series of novel hybrid compounds between 2-phenylbenzofuran and imidazole have been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-3-position with a naphthylacyl or bromophenacyl group, were vital for modulating cytotoxic activity. In particular, hybrid compound 15 was found to be the most potent compound against 4 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activity selectively against liver carcinoma (SMMC-7721). Copyright © 2012 Elsevier Ltd. All rights reserved. This article was published in Bioorg Med Chem Lett and referenced in Natural Products Chemistry & Research

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