alexa Detection of CD4(+) T-cell antibodies in a patient with idiopathic CD4 T lymphocytopenia and cryptococcal meningitis.


Journal of Neuroinfectious Diseases

Author(s): Salit RB, Hankey KG, Yi R, Rapoport AP, Mann DL

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Abstract Idiopathic CD4(+) T lymphocytopenia (ICL) is defined as a CD4(+) T-cell count <0.3 x 10(9)/l or <20\% of the total T-cell count on two occasions in the absence of any immunodeficiency disorder or therapy associated with reduced CD4(+) T-cell count. Although several mechanisms of ICL have been reported, the pathophysiology is still largely unknown. This case report describes a patient who presented with cryptococcal meningitis and was subsequently discovered to meet the criteria for ICL. Flow cytometric analysis of the patient's peripheral blood mononuclear cells revealed antibodies coating a much larger proportion of his CD4(+) T cells (33.61\%) than the CD4(+) T cells of normal donors (3.94 +/- 1.77\%). The reasons behind the development of these autoantibodies are explored. This article was published in Br J Haematol and referenced in Journal of Neuroinfectious Diseases

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