alexa Detection of gamma-aminobutyric acid in a living rat brain using in vivo microdialysis-capillary electrophoresis mass spectrometry.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Takada Y, Yoshida M, Sakairi M, Koizumi H

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Abstract Coupling of in vivo microdialysis with capillary electrophoresis/mass spectrometry (MD-CE/MS) was demonstrated. A microdialysis probe was inserted in the striatum of a rat brain and gamma-aminobutyric acid (GABA) in the brain was detected by CE/MS without any chemical treatment of the sample. MD-CE/MS is expected to be a useful technique for analyzing brain substances, because of the relatively small damage it causes to a living structure and the high selectivity of the analytical technique. This article was published in Rapid Commun Mass Spectrom and referenced in Pharmaceutica Analytica Acta

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