alexa Detection of putative loci affecting milk, health, and conformation traits in a US Holstein population using 105 microsatellite markers.


Journal of Drug Metabolism & Toxicology

Author(s): Van Tassell CP, Ashwell MS, Sonstegard TS

Abstract Share this page

Abstract Quantitative trait loci affecting milk yield, health, and conformation traits were studied for eight large US Holstein grandsire families by using the granddaughter design. A total of 105 microsatellite markers, located throughout the bovine genome, were selected for the scan. The data analyzed include genotypes for 35 markers in eight families not previously reported and genotypes for 70 markers reported previously in seven of those families. Analyses of markers previously reported were updated. Effects of marker alleles were analyzed for 38 traits, including traits for milk production, somatic cell score, productive life, conformation, calving ease, and 16 canonical traits derived from conformation and production traits. Permutation tests were used to calculate empirical trait-wise error rates. A trait-wise critical value of P = 0.1 was used to determine significance. Eight putative quantitative trait loci associated with 7 of the 35 new markers were identified within specific families. Two of these markers were associated with differences in strength and rump angle on chromosomes 4 and 9, respectively. Different markers were associated with protein percentage, milk yield, and somatic cell score on chromosomes 6, 7, and 10 in different families. Differences in the canonically transformed traits were associated with markers on chromosomes 5, 6, and 9. Additional marker-trait combinations were identified in the across-family tests, including effects on chromosomes 3, 4, and 9 for protein percentage, body depth, and canonical conformation traits, respectively. Additional markers are being added to allow interval analysis for putative quantitative trait loci that have been identified and to increase marker density. This article was published in J Dairy Sci and referenced in Journal of Drug Metabolism & Toxicology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version